Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway
نویسندگان
چکیده
1 Platform Degenerative Diseases, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany, 2 Department of Developmental Biology, Faculty of Biology, University of Göttingen, Göttingen, Germany, 3 Department of Zoology, Islamia College University, Peshawar, Pakistan, 4 Laboratory of Reproductive Neuroendocrinology, Department of Animal Sciences, Faculty of Biological Sciences, Quiad-i-Azam University, Islamabad, Pakistan, 5 DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany
منابع مشابه
Kisspeptin as a link between metabolism and reproduction: evidences from rodent and primate studies.
Changes in metabolic status gate reproductive activity by still incompletely deciphered mechanisms. Many neuropeptides have been shown to be involved in restraining hypothalamic gonadotropin releasing hormone (GnRH) release under conditions of negative energy balance. Broadly, on the basis of their effect on feeding, these can be grouped as orexigenic and anorexigenic neuropeptides. Reciprocall...
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The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons, KISS1R is expressed in other brain areas and peripheral tissues, which suggests that kisspeptin has additional functions beyond reproduction. Here, we studied the energetic and metabolic phenotype in mice lacking kisspep...
متن کاملKisspeptin and energy balance in reproduction.
Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons are now recognized as a central pathway responsible for conveying key homeostatic information to GNRH neurons. This pathway is likely to mediate the well-established link between energy balance and reproductive function. Thus, in states of severely altered energy balance (either negative or positive), fe...
متن کاملKisspeptin and the hypothalamic control of reproduction: lessons from the human.
The hypothalamic hormone GnRH is a central driver of pituitary gonadotropin secretion, controlling pulsatile gonadotropin secretion, modulating gonadal steroid feedback, and bringing about full fertility in the adult. Thus, understanding GnRH neuronal regulation is essential to understanding the neurohumoral control of human reproduction. Genetic tools were used in patients with GnRH deficiency...
متن کاملBeyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function
Uterine growth and endometrial gland formation (adenogenesis) and function, are essential for fertility and are controlled by estrogens and other regulators, whose nature and physiological relevance are yet to be elucidated. Kisspeptin, which signals via Kiss1r, is essential for fertility, primarily through its central control of the hypothalamic-pituitary-ovarian axis, but also likely through ...
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